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4th International Conference on Biomarkers and Clinical Research, will be organized around the theme “”

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A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Biomarker also called molecular marker and signature molecule.

Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer, occurrence of cancer, or patient outcome. They may include somatic genetic variants, epigenetic signatures, transcriptional changes and proteomic signatures. These indicators are based on biomolecules, such as nucleic acids and proteins, that can be detected in samples obtained from tissues through tumor biopsy or, more easily and non-invasively, from blood, saliva.

Cancer biomarker discovery and development falls into five conceptual phases: preclinical exploratory studies; clinical assay and validation; retrospective longitudinal studies; prospective screening; and randomized control trials

With the increasing sophistication of diagnostic processes and expanding knowledge about association between biomolecules, genomics and acute disease, interest in biomarkers is at an all-time high. Although there are many research studies into validating and understanding the prognostic and diagnostic value of biomarkers, this thematic series covers recent advances in the clinical applications of biomarkers.


Cancer biomarkers are biological molecules produced by the body or tumor in a person with cancer. Biomarker testing helps characterize alterations in the tumor. Biomarkers can be DNA, RNA, protein or metabolomics profiles that are specific to the tumor. Testing can include genomic testing to look at the DNA sequence, DNA or RNA tests to look for gene fusions, or tests to measure RNA or protein levels.

While prognostic biomarkers hint at the likely outcome of a patient with a particular disease regardless of their treatment, predictive biomarkers provide information on whether that patient will respond to a certain agent. Some markers provide both of these functions. For instance, estrogen receptor positivity in breast cancer patients indicates a favorable prognosis (providing prognostic information); at the same time, it means that the patient will probably respond to endocrine therapy.


The biomarker validation study represents a key step for the translation of the bench findings into clinical practice for tailored prescription or to accelerate the development of new drugs and other medical products. Biomarker validation is a multifaceted procedure that requires collaboration of multiple clinical centers and carries a significant financial burden and for which robust quantitative assays have been developed will enter the validation phase.

Biomarkers are of increasingly high importance in medicine, particularly in 'personalized medicine'. They are valuable for predicting prognosis and dose selection. Moreover, they may be helpful in detecting therapeutic and adverse responses and in patient stratification based on efficacy or safety prediction. Thus, biomarkers are essential tools for the selection of appropriate patients for treatment with certain drugs to and enable personalized medicine that is 'providing the right treatment to the right patient.

Digital biomarkers are defined as objective, quantifiable physiological and behavioral data that are collected and measured by means of digital devices such as portables, wearables, implantables, or digestibles. The data collected are typically used to explain, influence, and/or predict health-related outcomes.

Cancer can be treated by way of unique processes. The selection of therapy depends upon the location and grade of the tumor and the level of the sickness, as well as the general country of the affected person). Many experimental most cancers treatments also are under improvement. a few people with cancer will have handiest one treatment. But most of the people have a combination of treatments, consisting of surgical treatment with chemotherapy and/or radiation remedy. You could also have immunotherapy, focused remedy, or hormone remedy.

Biomarker research has been revolutionized by the development of high-throughput technologies and artificial intelligence methods, yielding a prolific biomarker discovery phase. Additional efforts are needed now to develop the analytical infrastructure necessary to generate, integrate and analyze multi-omics data effectively.

Diagnostic testing of malignancy includes the checks achieved by way of a pathologist to verify the segment of disorder, length of the tumor, region infected via the tumor, and so forth unique obsessive and histopathological procedures are utilized in malignancy conclusion. A portion of the simple systems for most cancers determination are biopsy, MRI, X-Ray and so forth A portion of various strategies which can be normally applied in recent times to apprehend or distinguish the malignancies beginning from an organ are endoscopy for gastrointestinal tumors, mammography for bosom illnesses and so on one of the lately designed strategies for area of organ characterized malignant growths is atomic medicinal drug imaging.